Rudolf Aebersold: Catalogue data in Spring Semester 2016

Name Prof. Dr. Rudolf Aebersold
FieldSystembiologie
E-mailaebersold@imsb.biol.ethz.ch
DepartmentBiology
RelationshipProfessor emeritus

NumberTitleECTSHoursLecturers
551-0002-AALGeneral Biology II
Enrolment ONLY for MSc students with a decree declaring this course unit as an additional admission requirement.

Any other students (e.g. incoming exchange students, doctoral students) CANNOT enrol for this course unit.
3 credits6RU. Sauer, R. Aebersold, H.‑M. Fischer, W. Gruissem
AbstractBasics of structure, formation and function of cells and biomacromolecules, principles of metabolism, basic molecular genetics, form and function of plants.
ObjectiveThe understanding of some basic concepts of biology: the hierarchy of the structural levels of biological organisation, with particular emphasis on the cell and its functions, the fundamentals of metabolism and molecular genetics, as well as form and function of vascular plants.
ContentThe structure and function of biomacromolecules; basics of metabolism; tour of the cell; membrane structure and function; basic energetics of cellular processes; respiration, photosynthesis; cell cycle, from gene to protein; bacteria and archaea; structure and growth of vascular plants, resource acquisition and transport, soil and plant nutrition.

The content of this lecture is identical to the "Allgemeine Biologie II" with the following Campbell chapters:

16 The Molecular Basis of Inheritance
17 From Gene to Protein
18 Regulation of Gene Expression
19 Viruses
20, 38 Biotechnology, Biosafety
27 Bacteria and Archae
28 Protists
31 Fungi
29, 30 Plant Diversity I & II
35 Plant Structure, Growth, and Development
36 Resource Acquisition and Transport
37 Soil and Plant Nutrition
38 Angiosperm Reproduction and Biotechnology
39 Plant Responses to Internal and External Signals
Lecture notesNo script
LiteratureN. A. Campbell, J. B. Reece: "Biology" (8th edition); Benjamin Cummings, San Francisco 2008.
Prerequisites / NoticeBasic general and organic chemistry
551-0002-00LGeneral Biology II3 credits3GU. Sauer, R. Aebersold, H.‑M. Fischer, W. Gruissem
AbstractBasics of molecular biology (gene expression and its regulation; from gene to protein); evolution of biological diversity (bacteria, archaea, protists, fungi, plants); basics of the physiology of higher plants (structure, growth, development, nutrition, transport, reproduction)
ObjectiveThe understanding of basic concepts in biology: gene expression, its control and regulation; life histories of pro- and eucaryotic microorgamisms; structure, function, and reprodction of higher plants.
ContentFrom gene to protein; molecular genetics of microbial systems; structural and metabolic diversity of prokaryotes; diversity of eukaryotic microorganisms; the eukaryotic genome; regulation of gene expression; the genetic basis of the development of multicellullar organisms. Plant physiology: structure and growth, physiology of photosynthesis incl. C4 and CAM, nutrition and transport processes, reproduction and development, response to internal and external signals.

The following Campbell chapters will be covered:

16 The Molecular Basis of Inheritance
17 From Gene to Protein
18 Regulation of Gene Expression
19 Viruses
20, 38 Biotechnology, Biosafety
27 Bacteria and Archae
28 Protists
31 Fungi
29, 30 Plant Diversity I & II
35 Plant Structure, Growth, and Development
36 Resource Acquisition and Transport
37 Soil and Plant Nutrition
38 Angiosperm Reproduction and Biotechnology
39 Plant Responses to Internal and External Signals
Lecture notesno script
LiteratureN. A. Campbell, J. B. Reece: "Biology" (8th edition); Pearson, San Francisco 2008.
Prerequisites / NoticeThe lecture is the second in a series of two lectures given over two semesters for students of agricultural and food sciences, as well as of environmental sciences.
551-0224-00LAdvanced Proteomics Restricted registration - show details
For master students from the 2nd semester on, also doctoral candidates and post docs.
4 credits6GR. Aebersold
AbstractGoal of the course is to analyze current and newly emerging technologies and approaches in protein and proteome analysis with regard to their application in biology, biotechnology and medicine.
Format: Introduction by instructor followed by discussions stimulated by reading assignments and exercises.
ObjectiveTo discuss current and newly emerging technologies and approaches in protein and proteome analysis with regard to their applications in biology, biotechnology, medicine and systems biology.
ContentBlock course teaching current methods for the acquisition and processing of proteomic datasets.
Prerequisites / NoticeNumber of people: Not exceeding 30.
Students from ETHZ, Uni Zurich and University of Basel
Non-ETH students must register at ETH Zurich as special students http://www.rektorat.ethz.ch/students/admission/auditors/index_EN
551-0324-00LSystems Biology6 credits4VR. Aebersold, B. Christen, M. Claassen, E. Hafen, U. Sauer
AbstractIntroduction to experimental and computational methods of systems biology. By using baker’s yeast as a thread through the series, we focus on global methods for analysis of and interference with biological functions. Illustrative applications to other organisms will highlight medical and biotechnological aspects.
Objective- obtain an overview of global analytical methods
- obtain an overview of computational methods in systems biology
- understand the concepts of systems biology
ContentOverview of global analytical methods (e.g. DNA arrays, proteomics, metabolomics, fluxes etc), global interference methods (siRNA, mutant libraries, synthetic lethality etc.) and imaging methods. Introduction to mass spectrometry and proteomics. Concepts of metabolism in microbes and higher cells. Systems biology of developmental processes. Concepts of mathematical modeling and applications of computational systems biology.
Lecture notesno script
LiteratureThe course is not taught by a particular book, but some books are suggested for further reading:

- Systems biology in Practice by Klipp, Herwig, Kowald, Wierling und Lehrach. Wiley-VCH 2005