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Daniel J. Müller: Katalogdaten im Herbstsemester 2018

NameHerr Prof. Dr. Daniel J. Müller
Professur für Biophysik
ETH Zürich, D-BSSE, BSA M 714
Mattenstrasse 26
4058 Basel
Telefon+41 61 387 33 07
Fax+41 61 387 39 94
BeziehungOrdentlicher Professor

636-0102-00LAdvanced Bioengineering4 KP3SS. Panke, Y. Benenson, P. S. Dittrich, M. Fussenegger, A. Hierlemann, M. H. Khammash, D. J. Müller, R. Paro, R. Platt, T. Schroeder
KurzbeschreibungThis course provides an overview of modern concepts of bioengineering across different levels of complexity, from single molecules to systems, microscaled reactors to production environments, and across different fields of applications
LernzielStudents will be able to recognize major developments in bioengineering across different organisms and levels of complexity and be able to relate it to major technological and conceptual advances in the underlying sciences.
InhaltMolecular and cellular engineering; Synthetic biology: Engineering strategies in biology; from single molecules to systems; downscaling bioengineering; Bioengineering in chemistry, pharmaceutical sciences, and diagnostics, personalized medicine.
SkriptHandouts during class
LiteraturWill be announced during the course
636-0104-00LBiophysical Methods
Attention: This course was offered in previous semesters with the number: 626-0010-00L "Nanomachines of the Cell (Part I): Principles". Students that already passed course 626-0010-00 cannot receive credits for course 636-0104-00.
4 KP3GD. J. Müller
KurzbeschreibungStudents will be imparted knowledge in basic and advanced biophysical methods applied to problems in molecular biotechnology. The course is fundamental to applying the methods in their daily and advanced research routines. The students will learn the physical basis of the methods as well as their limitations and possibilities to address existing and future topics in molecular biotechnology.
LernzielGain of interdisciplinary competence in experimental and theoretical research, which qualifies for academic scientific work (master's or doctoral thesis) as well as for research in a biotechnology or a pharmaceutical company. The module is of general use in courses focused on modern biomolecular technologies, systems biology and systems engineering.
InhaltThe students will learn basic and advanced knowledge in applying biophysical methods to address problems and overcome challenges in biotechnology, cell biology and life sciences in general. The biological and physical possibilities and limitations of the methods will be discussed and critically evaluated. By the end of the course the students will have assimilated knowledge on a portfolio of biophysical tools widening their research capabilities and aptitude.
The biophysical methods to be taught will include:
• Light microscopy: Resolution limit of light microscopy, fluorescence, GFP, fluorescence microscopy, DIC, phase contrast, difference between wide-field and confocal microscopy
• Super resolution optical microscopy: STED, PALM, STORM, other variations
• Electron microscopy: Scanning electron microscopy, transmission electron microscopy, electron tomography, cryo-electron microscopy, single particle analysis and averaging, tomography, sectioning, negative stain
• X-ray, electron and neutron diffraction
• MRI Imaging
• Scanning tunnelling microscopy and atomic force microscopy
• Patch clamp technologies: Principles of patch clamp analysis and application. Various patch clamp approaches used in research and industry
• Surface plasmon resonance-based biosensors
• Molecular pore-based sensors and sequencing devices
• Mechanical molecular and cellular assembly devices
• Optical and magnetic tweezers
• CD spectroscopy
• Optogenetics
• Molecular dynamics simulations
SkriptHand out will be given to students at lecture.
LiteraturMethods in Molecular Biophysics (5th edition), Serdyuk et al., Cambridge University Press
Biochemistry (5th edition), Berg, Tymoczko, Stryer; ISBN 0-7167-4684-0, Freeman
Bioanalytics, Lottspeich & Engels, Wiley VCH, ISBN-10: 3527339191
Cell Biology, Pollard & Earnshaw; ISBN:0-7216-3997-6, Saunder, Pennsylvania
Methods in Modern Biophysics, Nölting, 3rd Edition, Springer, ISBN-10: 3642030211
Voraussetzungen / BesonderesThe module is composed of 3 SWS (3 hours/week): 2-hour lecture, 1-hour seminar. For the seminar, students will prepare oral presentations on specific in-depth subjects with/under the guidance of the teacher.
636-0301-00LCurrent Topics in Biosystems Science and Engineering
For doctoral students only.
Master's students cannot receive credits for the seminar.
2 KP1SR. Platt, N. Beerenwinkel, Y. Benenson, K. M. Borgwardt, P. S. Dittrich, M. Fussenegger, A. Hierlemann, D. Iber, M. H. Khammash, D. J. Müller, S. Panke, R. Paro, S. Reddy, T. Schroeder, T. Stadler, J. Stelling
KurzbeschreibungThis seminar will feature invited lectures about recent advances and developments in systems biology, including topics from biology, bioengineering, and computational biology.
LernzielTo provide an overview of current systems biology research.
InhaltThe final list of topics will be available at https://www.bsse.ethz.ch/news-and-events/seminar-series.html