401-8625-00L Statistical Methods in Clinical Research (University of Zurich)
Semester | Autumn Semester 2015 |
Lecturers | University lecturers |
Periodicity | yearly recurring course |
Language of instruction | English |
Comment | No enrolment to this course at ETH Zurich. Book the corresponding module directly at UZH. UZH Module Code: STA404 Mind the enrolment deadlines at UZH: Link |
Abstract | Discussion of the different statistical methods that are used in clinical research. |
Objective | |
Content | Discussion of the different statistical methods that are used in clinical research. Among other subjects the following will be introduced: sample size calculation, randomization and blinding, analysis of clinical trials (parallel groups design, analysis of covariance, crossover design, equivalence studies), intention-to-treat analysis, multiple testing, group sequential methods, adaptive designs, diagnostic studies, and agreement studies. |
Literature | - Matthews, J. N. S. (2006). Introduction to Randomized Controlled Clinical Trials. Chapman & Hall/CRC Texts in Statistical Science. - Cook, T. D. and DeMets, L. D. (2008). Introduction to Statistical Methods for Clinical Trials. Chapman & Hall/CRC Texts in Statistical Science. - Pepe, M. (2003). The Statistical Evaluation of Medical Tests for Classification and Prediction. Oxford University Press. - Schumacher, M. and Schulgen, G. (2008). Methodik klinischer Studien. Springer, Berlin. |
Prerequisites / Notice | Basic knowlegde of the programming language R, sufficient knowledge in calculus, linear algebra, probability, statistics |