376-1611-00L Biomedical Interfaces
|Semester||Spring Semester 2016|
|Lecturers||I. Schön, V. Vogel, R. Konradi|
|Periodicity||yearly recurring course|
|Language of instruction||German|
|Abstract||Based on the understanding of how biomolecules and living cells interact with materials, prototypical requirements for materials and material surfaces are developed. |
The concepts are illustrated in the context of specific biomedical applications. I.e. we present strategies that exploit the self-assembly of (bio)molecular building blocks.
|Objective||Using the knowledge of cell-to-cell and cell-to-matrix interactions, the students will be able to define essential requirements how to functionalize materials in the context of specific biomedical applications.|
Based on the understanding of the basic principles of self-organizing systems, the students will be able to predict shape, size and functional characteristics of a desired structure by choosing adequate molecules and appropriate solution conditions for their assembly. Furthermore, the students will acquire knowledge about methods for the functionalization of conventional materials in order to tailor their biocompatibility or function.
In the accompanying seminar, the students will learn how to address scientific questions by original publications. The students will learn how to read, evaluate, and criticize scientific literature in the context of biomaterials.
|Content||- protein-surface interactions|
- anti-adhesive surface coatings
- bacteria-surface interactions
- cell-nanoparticle interactions
- drug delivery systems
- cell-matrix interactions
- soft tissue engineering
|Lecture notes||Handouts of the lecture can be accessed online.|
|Literature||Selected chapters of|
- Biomaterials Science: an Introduction to Materials in Medicine, by B. Ratner, 3rd Ed. Academic Press (2013).
- Biomimetic Materials and Design: Biointerfacial Strategies, Tissue Engineering and Targeted Drug Delivery, by A.K. Dillow and A.M. Lowman, CRC Press (2002).
- Biomaterials: Principles and Practices, by J.Y. Wong et al., CRC Press (2013).
- Molecular Biology of the Cell, by B. Alberts et al., Taylor & Francis, 5th Ed. (2007).
Detailed literature references will be provided in the lectures.
|Prerequisites / Notice||This interdisciplinary class addresses students from all disciplines at the Bachelor level. We premise a profound basic knowledge about cell biology and biochemistry.|