Suchergebnis: Katalogdaten im Herbstsemester 2018

Gesundheitswissenschaften und Technologie Master Information
Vertiefung in Molekulare Gesundheitswissenschaften
Wahlfächer
Wahlfächer II
NummerTitelTypECTSUmfangDozierende
327-2125-00LMicroscopy Training SEM I - Introduction to SEM Belegung eingeschränkt - Details anzeigen
Number of participants limited. In case of overbooking, the course will be repeated once.

Master students will have priority over PhD students. PhD students may still enrol, but will be asked for a fee (Link).

SEM1 registration form: Link ).
W2 KP3PK. Kunze, A. G. Bittermann, L. Grafulha Morales, J. Reuteler
KurzbeschreibungDer Einführungskurs in Rasterelektronenmikroskopie (SEM) betont praktisches Lernen. Die Studierenden haben die Möglichkeit an zwei Elektronenmikroskopen ihre eigenen Proben oder Standard-Testproben zu untersuchen, sowie von ScopeM-Wissenschafler vorbereitete Übungen zu lösen.
Lernziel- Set-up, align and operate a SEM successfully and safely.
- Accomplish imaging tasks successfully and optimize microscope performances.
- Master the operation of a low-vacuum and field-emission SEM and EDX instrument.
- Perform sample preparation with corresponding techniques and equipment for imaging and analysis
- Acquire techniques in obtaining secondary electron and backscatter electron micrographs
- Perform EDX qualitative and semi-quantitative analysis
InhaltDuring the course, students learn through lectures, demonstrations, and hands-on sessions how to setup and operate SEM instruments, including low-vacuum and low-voltage applications.
This course gives basic skills for students new to SEM. At the end of the course, students with no prior experience are able to align a SEM, to obtain secondary electron (SE) and backscatter electron (BSE) micrographs and to perform energy dispersive X-ray spectroscopy (EDX) qualitative and semi-quantitative analysis. The procedures to better utilize SEM to solve practical problems and to optimize SEM analysis for a wide range of materials will be emphasized.

- Discussion of students' sample/interest
- Introduction and discussion on Electron Microscopy and instrumentation
- Lectures on electron sources, electron lenses and probe formation
- Lectures on beam/specimen interaction, image formation, image contrast and imaging modes.
- Lectures on sample preparation techniques for EM
- Brief description and demonstration of the SEM microscope
- Practice on beam/specimen interaction, image formation, image contrast (and image processing)
- Student participation on sample preparation techniques
- Scanning Electron Microscopy lab exercises: setup and operate the instrument under various imaging modalities
- Lecture and demonstrations on X-ray micro-analysis (theory and detection), qualitative and semi-quantitative EDX and point analysis, linescans and spectral mapping
- Practice on real-world samples and report results
Literatur- Detailed course manual
- Williams, Carter: Transmission Electron Microscopy, Plenum Press, 1996
- Hawkes, Valdre: Biophysical Electron Microscopy, Academic Press, 1990
- Egerton: Physical Principles of Electron Microscopy: an introduction to TEM, SEM and AEM, Springer Verlag, 2007
Voraussetzungen / BesonderesNo mandatory prerequisites. Please consider the prior attendance to EM Basic lectures (551- 1618-00V; 227-0390-00L; 327-0703-00L) as suggested prerequisite.
327-2126-00LMicroscopy Training TEM I - Introduction to TEM Belegung eingeschränkt - Details anzeigen
Number of participants limited.In case of overbooking, the course could be repeated once.

Master students will have priority over PhD students. PhD students may still enroll, but will be asked for a fee (Link.
TEM1 registration form: Link).
W2 KP3PM. Willinger, E. J. Barthazy Meier, A. G. Bittermann, F. Gramm
KurzbeschreibungDer Einführungskurs in Transmissionselektronenmikroskopie (TEM) bietet neuen Nutzern die Möglichkeit theoretisches Wissen und praktische Kenntnisse in TEM zu erwerben
Lernziel- Overview of TEM theory, instrumentation, operation and applications.
- Alignment and operation of a TEM, as well as acquisition and interpretation of images, diffraction patterns, accomplishing basic tasks successfully.
- Knowledge of electron imaging modes (including Scanning Transmission Electron Microscopy), magnification calibration, and image acquisition using CCD cameras.
- To set up the TEM to acquire diffraction patterns, perform camera length calibration, as well as measure and interpret diffraction patterns.
- Overview of techniques for specimen preparation.
InhaltUsing two Transmission Electron Microscopes the students learn how to align a TEM, select parameters for acquisition of images in bright field (BF) and dark field (DF), perform scanning transmission electron microscopy (STEM) imaging, phase contrast imaging, and acquire electron diffraction patterns. The participants will also learn basic and advanced use of digital cameras and digital imaging methods.

- Introduction and discussion on Electron Microscopy and instrumentation.
- Lectures on electron sources, electron lenses and probe formation.
- Lectures on beam/specimen interaction, image formation, image contrast and imaging modes.
- Lectures on sample preparation techniques for EM.
- Brief description and demonstration of the TEM microscope.
- Practice on beam/specimen interaction, image formation, Image contrast (and image processing).
- Demonstration of Transmission Electron Microscopes and imaging modes (Phase contrast, BF, DF, STEM).
- Student participation on sample preparation techniques.
- Transmission Electron Microscopy lab exercises: setup and operate the instrument under various imaging modalities.
- TEM alignment, calibration, correction to improve image contrast and quality.
- Electron diffraction.
- Practice on real-world samples and report results.
Literatur- Detailed course manual
- Williams, Carter: Transmission Electron Microscopy, Plenum Press, 1996
- Hawkes, Valdre: Biophysical Electron Microscopy, Academic Press, 1990
- Egerton: Physical Principles of Electron Microscopy: an introduction to TEM, SEM and AEM, Springer Verlag, 2007
Voraussetzungen / BesonderesNo mandatory prerequisites. Please consider the prior attendance to EM Basic lectures (551- 1618-00V; 227-0390-00L; 327-0703-00L) as suggested prerequisite.
376-0121-00LMultiscale Bone Biomechanics Belegung eingeschränkt - Details anzeigen
Number of participants limited to 30
W6 KP4SR. Müller
KurzbeschreibungThe seminar provides state-of-the-art insight to the biomechanical function of bone from molecules, to cells, tissue and up to the organ. Multiscale imaging and simulation allows linking different levels of hierarchy, where systems biology helps understanding the mechanobiological response of bone to loading and injury in scenarios relevant for personalized health and translational medicine.
LernzielThe learning objectives include 1. advanced knowledge of the state-of-the-are in multiscale bone biomechanics; 2. basic understanding of the biological principles governing bone in health, disease and treatment from molecules, to cells, tissue and up to the organ; 3. good understanding of the prevalent biomechanical testing and imaging techniques on the various levels of bone hierarchy; 4. practical implementation of state-of-the-art multiscale simulation techniques; 5. improved programing skills through the use of 4th generation scripting language; 6. hands on experience in designing solutions for clinical and industrial problems; 7. encouragement of critical thinking and creating an environment for independent and self-directed studying.
InhaltBone is one of the most investigated biological materials due to its primary function of providing skeletal stability. Bone is susceptible to different local stimuli including mechanical forces and has great capabilities in adapting its mechanical properties to the changes in its environment. Nevertheless, aging or hormonal changes can make bone lose its ability to remodel appropriately, with loss of strength and increased fracture risk as a result, leading to devastating diseases such as osteoporosis. To better understand the biomechanical function of bone, one has to understand the hierarchical organization of this fascinating material down from the molecules, to the cells, tissue and up to the organ. Multiscale imaging and simulation allows to link these different levels of hierarchy. Incorporating systems biology approaches, not only biomechanical strength of the material can be assessed but also the mechanobiological response of the bone triggered by loading and injury in scenarios relevant for personalized health and translational medicine. Watching cells working together to build and repair bone in a coordinated fashion is a spectacle, which will need dynamic image content and deep discussions in the lecture room to probe the imagination of the individual student interested in the topic. For the seminar, concepts of video lectures will be used in a flipped class room setup, where students can study the basic biology, engineering and mathematical concepts in video tutorials online (TORQUES). All videos and animations will be incorporated in Moodle and eSkript allowing studying and interactive course participation online. It is anticipated that the students need to prepare 2x45 minutes for the study of the actual lecture material. On the Friday afternoon, the first time slot (12-13) will be used for students, who want to schedule one-to-one meetings with the lecturer/tutors to discuss course content. In the later time slots (13-16), short clips with video/animation content will be used to introduce problems and discuss specific scientific findings using multiscale imaging and simulation technology in a flipped classroom. The students will have to form small groups to try to solve such problems and to present their solutions for advanced multiscale investigation of bone ranging from basic science to personalized health and onto translational medicine. Towards the end of the semester, students will have to present self-selected publications associated with the different topics of the lecture identified through PubMed or the Web of Science.
SkriptMaterial will be provided in Moodle and eScript (eskript.ethz.ch).
Voraussetzungen / BesonderesSeminar will be held in English.
376-1151-00LTranslation of Basic Research Findings from Genetics and Molecular Mechanisms of Aging Belegung eingeschränkt - Details anzeigen
Number of participants limited to 30.
W3 KP2VC. Ewald
KurzbeschreibungRecently, several start-up companies are aiming to translate basic molecular findings into new drugs/therapeutic interventions to slow aging or post-pone age-related diseases (e.g., Google founded Calico or Craig Venter's Human Longevity, Inc.). This course will teach students the basic skill sets to formulate their own ideas, design experiments to test them and explains the next steps to translat
LernzielThe overall goal of this course is to be able to analyse current therapeutic interventions to identify an unmet need in molecular biology of aging and apply scientific thinking to discover new mechanisms that could be used as a novel therapeutic intervention.
Learning objectives include:
1. Evaluate the current problem of our aging population, the impact of age-dependent diseases and current strategies to prevent these age-dependent diseases.
2. Analyse/compare current molecular/genetic strategies that address these aging problems.
3. Analyse case studies about biotech companies in the aging sector. Apply the scientific methods to formulate basic research questions to address these problems.
4. Generate own hypotheses (educated guess/idea), design experiments to test them, and map out the next steps to translate them.
InhaltOverview of aging and age-related diseases. Key discoveries in molecular biology of aging. Case studies of biotech companies addressing age-related complications. Brief introduction from bench to bedside with focus on start-up companies.
Voraussetzungen / BesonderesNo compulsory prerequisites, but student should have basic knowledge about genetics and molecular biology.
376-1353-00LNanostructured Materials SafetyW2 KP1VP. Wick
KurzbeschreibungFundamentals in nanostructured material - living system interactions focusing on the main exposure routes, lung, gastrointestinal tract, skin and intravenous injection
LernzielUnderstanding the potential side effects of nanomaterials in a context-specific way, enabling to evaluate nanomaterial safety and provide knowledge to de-sign safer materials
SkriptHandouts provided during the classes and references therein as well as primary literature as case studies will be posted to the course website
Voraussetzungen / Besonderescourse "Introduction to Toxicology"
376-1622-00LPractical Methods in Tissue Engineering Belegung eingeschränkt - Details anzeigen
Number of participants limited to 16
W5 KP4PK. Würtz-Kozak, O. Krupkova, M. Zenobi-Wong
KurzbeschreibungThe goal of this course is to teach MSc students the necessary skills for doing research in the fields of tissue engineering and regenerative medicine.
LernzielPractical exercises and demonstrations on topics including sterile cell culture, light microscopy and histology, protein and gene expression analysis, and viability assays are covered. The advantages of 3D cell cultures will be discussed and practical work on manufacturing and evaluating hydrogels and scaffolds for tissue engineering will be performed in small groups. In addition to practical lab work, the course will teach skills in data acquisition/analysis.
551-0223-00LImmunology IIIW4 KP2VM. Kopf, M. Bachmann, S. B. Freigang, J. Kisielow, A. Lanzavecchia, S. R. Leibundgut, A. Oxenius, R. Spörri, L. Tortola
KurzbeschreibungDiese Vorlesung liefert einen detaillierten Einblick in die
- Entwicklung von T Zellen und B Zellen
- Dynamik einer Immunantwort bei akuten und chronischen Infektionen
- Mechanismen von Immunpathologie
- neue Impfstoffstrategien
LernzielSie verstehen
- die Entwicklung, Aktivierung, und Differenzierung verschiedener Typen von T Zellen und deren Effektormechanismen während einer Immunantwort
- die Erkennung von pathogenen Mikroorganismen und molekulare Ereignisse nach Infektion einer Zelle
- Ereignisse und Signale für die Reifung von naiven B Zellen zu antikörperproduzierenden Plasmazellen und Gedächtniszellen,
- Optimierung von B Zellantworten durch das intelligente Design neuer Impfstoffe
Inhalto Development and selection of CD4 and CD8 T cells, natural killer T cells (NKT), and regulatory T cells (Treg)
o NK T cells and responses to lipid antigens
o Differentiation, characterization, and function of CD4 T cell subsets such as Th1, Th2, and Th17
o Overview of cytokines and their effector function
o Co-stimulation (signals 1-3)
o Dendritic cells
o Evolution of the "Danger" concept
o Cells expressing Pattern Recognition Receptors and their downstream signals
o T cell function and dysfunction in acute and chronic viral infections
LiteraturUnterlagen zur Vorlesung sind erhältlich bei:
Link
Voraussetzungen / BesonderesImmunology I and II recommended but not compulsory
551-0512-00LCurrent Topics in Molecular and Cellular Neurobiology Belegung eingeschränkt - Details anzeigen
Findet dieses Semester nicht statt.
Number of participants limited to 8.
W2 KP1SU. Suter
KurzbeschreibungThe course is a literature seminar or "journal club". Each Friday a student, or a member of the Suter Lab in the Institute of Molecular Health Sciences, will present a paper from the recent literature.
LernzielThe course introduces you to recent developments in the fields of cellular and molecular neurobiology. It also supports you to develop your skills in critically reading the scientific literature. You should be able to grasp what the authors wanted to learn i.e. their goals, why the authors chose the experimental approach they used, the strengths and weaknesses of the experiments and the data presented, and how the work fits into the wider literature in the field. You will present one paper yourself, which provides you with practice in public speaking.
InhaltYou will present one paper yourself. Give an introduction to the field of the paper, then show and comment on the main results (all the papers we present are available online, so you can show original figures with a beamer). Finish with a summary of the main points and a discussion of their significance.
You are expected to take part in the discussion and to ask questions. To prepare for this you should read all the papers beforehand (they will be announced a week in advance of the presentation).
SkriptPresentations will be made available after the seminars.
Voraussetzungen / BesonderesYou must attend at least 80% of the journal clubs, and give a presentation of your own. At the end of the semester there will be a 30 minute oral exam on the material presented during the semester. The grade will be based on the exam (45%), your presentation (45%), and a contribution based on your active participation in discussion of other presentations (10%).
551-0571-00LFrom DNA to Diversity (University of Zurich)
Der Kurs muss direkt an der UZH belegt werden.
UZH Modulkürzel: BIO336

Beachten Sie die Einschreibungstermine an der UZH: Link
W2 KP2VA. Hajnal, D. Bopp
KurzbeschreibungThe evolution of the various body-plans is investigated by means of comparison of developmentally essential control genes of molecularly analysed model organisms.
LernzielBy the end of this module, each student should be able to
- recognize the universal principles underlying the development of
different animal body plans.
- explain how the genes encoding the molecular toolkit have evolved
to create animal diversity.
- relate changes in gene structure or function to evolutionary
changes in animal development.
Key skills:
By the end of this module, each student should be able to
- present and discuss a relevant evolutionary topic in an oral
presentation
- select and integrate key concepts in animal evolution from
primary literature
- participate in discussions on topics presented by others
551-1003-00LMethoden der Biologischen Analytik Information W3 KP3GR. Aebersold, M. Badertscher, K. Weis
Kurzbeschreibung529-1042-00
Grundlagen der wichtigsten Trennmethoden und der Interpretation von Molekülspektren.

551-1003-00
Der Kurs befasst sich mit den Methoden und ausgewählten Anwendungen von Methoden der Nukleinsäuresequenzierung, der massenspektrometrischen Analyse von Proteinen und Proteomen und Licht-und Fluoreszenz gestützten Methoden der Mikroskopie.
Lernziel529-1042-00
Kenntnis der notwendigen Grundlagen und der Anwendungsmöglichkeiten für den Einsatz von relevanten spektroskopischen und Trennmethoden in der analytisch-chemischen Praxis.

551-1003-00
Kenntnis der notwendigen Grundlagen und der Anwendungsmöglichkeiten der Methoden für die Bestimmung von Nukleinsäuresequenzen, der massenspektrometrischen Analyse von Proteinen und Proteomen und Licht-und Fluoreszenz gestützten Methoden der Mikroskopie.
Inhalt529-1042-00
Anwendungsorientierte Grundlagen der organischen Instrumentalanalytik und des empirischen Einsatzes von Methoden der Strukturaufklärung (Massenspektrometrie, NMR-, IR-, UV/VIS-Spektroskopie). Grundlagen und Anwendung chromatographischer und elektrophoretischer Trennverfahren. Praxisnahe Anwendung und Vertiefung des Grundwissens anhand von Übungen.

551-1003-00
Der Kurs setzt sich zusammen aus Vorlesungen, die die theoretischen und technischen Grundlagen der betreffenden analytischen Methoden vermitteln und Übungen, die sich mit den Anwendungen der analytischen Methoden in der modernen experimentellen Biologie befassen.
Skript529-1042-00
Ein umfangreiches Skript ist im HCI-Shop erhältlich. Eine Kurzfassung des Teils "Spektroskopie" definiert die für die Prüfung dieses Teils relevanten Themen.
Literatur529-1042-00
- Pretsch E., Bühlmann P., Badertscher M. Structure Determination of Organic Compounds, 5th revised and enlarged English edition, Springer-Verlag, Berlin 2009;
- Pretsch E., Bühlmann P., Badertscher M., Spektroskopische Daten zur Strukturaufklärung organischer Verbindungen, fünfte Auflage, Springer-Verlag, Berlin 2010;
- D.A. Skoog, J.J. Leary, Instrumentelle Analytik, Grundlagen, Geräte, Anwendungen, Springer, Berlin, 1996;
- K. Cammann, Instrumentelle Analytische Chemie, Verfahren, Anwendungen, Qualitätssicherung, Spektrum Akademischer Verlag, Heidelberg, 2001;
- R. Kellner, J.-M. Mermet, M. Otto, H.M. Widmer, Analytical Chemistry, Wiley-VCH Verlag, Weinheim, 1998;
- K. Robards, P.R.Haddad, P.E. Jackson, Principles and practice of modern chromatographic methods, Academic Press, London, 1994;
Voraussetzungen / Besonderes529-1042-00
Voraussetzungen:
- 529-1001-01 V "Allgemeine Chemie I (für Biol./Pharm.Wiss.)"
- 529-1001-00 P "Allgemeine Chemie I (für Biol./Pharm.Wiss.)"
- 529-1011-00 G "Organische Chemie I (für Biol./Pharm.Wiss.)"
551-1105-00LGlycobiologyW4 KP2VM. Aebi, T. Hennet
KurzbeschreibungStructural principles, nomenclature and different classes of glycosylation. The different pathways of N- and O-linked protein glycosylation and glycolipid biosynthesis in prokaryotes and eukaryotes are discussed. Specific glycan binding proteins and their role in deciphering the glycan code are presented. The role of glycans in infectious diseases, antigen mimicry and autoimmunity are discussed.
LernzielDetailed knowledge in 1) the different areas of prokaryotic and eukaryotic glycobiology, in particular in the biosynthesis of glycoproteins and glycolipids, 2) the cellular machinery required for these pathways, 3) the principles of carbohydrate/protein interaction, 4) the function of lectins, 5) the role of glycans in infectious disease.
InhaltStructure and linkages; analytical approaches; N-linked protein glycosylation (ER, Golgi); glycan-assisted protein folding and quality control; O-linked protein glycosylation; glucosaminoglycans; glycolipids; prokaryotic glycosylation pathways; lectins; glycans and infectious disease
Skripthandouts
LiteraturIntroduction to Glycobiology; M.E.Taylor, K.Drickamer, Oxford University Press, 2003
Essentials of Glycobiology (third edition); A.Varki et al. Cold Spring Harbor Laboratory Press, 2017
Voraussetzungen / BesonderesThe course will be in English. It will include the preparation of short essays (marked) about defined topics in Glycobiology.
551-1145-00LViral and non-Viral Vectors for Human Gene-Therapy - from Pathogens to Safe Medical Applications
Der Kurs muss direkt an der UZH belegt werden.
UZH Modulkürzel: BIO708

Beachten Sie die Einschreibungstermine an der UZH: Link
W2 KP3VUni-Dozierende
KurzbeschreibungBasic aspects of virology, the viral mechanisms for transfer of genetic material into cells, different vector-systems and target cells, animal models, specific applications for inborn diseases of the immune system and of metabolism, adverse effects, and new developments of vector systems will be taught.
LernzielKnowledge of important viral and non-viral vector systems.
Knowledge of application in human diseases.
Knowledge of limiting factors.
551-1153-00LSystems Biology of Metabolism
Number of participants limited to 15.
W4 KP2VU. Sauer, N. Zamboni, M. Zampieri
KurzbeschreibungStarting from contemporary biological problems related to metabolism, the course focuses on systems biological approaches to address them. In a problem-oriented, this-is-how-it-is-done manner, we thereby teach modern methods and concepts.
LernzielDevelop a deeper understanding of how relevant biological problems can be solved, thereby providing advanced insights to key experimental and computational methods in systems biology.
InhaltThe course will be given as a mixture of lectures, studies of original research and guided discussions that focus on current research topics. For each particular problem studied, we will work out how the various methods work and what their capabilities/limits are. The problem areas range from microbial metabolism to cancer cell metabolism and from metabolic networks to regulation networks in populations and single cells. Key methods to be covered are various modeling approaches, metabolic flux analyses, metabolomics and other omics.
SkriptScript and original publications will be supplied during the course.
Voraussetzungen / BesonderesThe course extends many of the generally introduced concepts and methods of the Concept Course in Systems Biology. It requires a good knowledge of biochemistry and basics of mathematics and chemistry.
551-1171-00LImmunology: from Milestones to Current TopicsW4 KP2SB. Ludewig, J. Kisielow, M. Kopf, A. Oxenius, Uni-Dozierende
KurzbeschreibungMilestones in Immunology: on old concepts and modern experiments
LernzielThe course will cover six grand topics in immunology (B cells, innate immunity, antigen presentation, tumor immunity, thymus and T cells, cytotoxic T cells and NK cells) and for each grand topic four hours will be allocated. During the first double hour, historical milestone papers will be presented by the supervisor providing an overview on the development of the conceptional framework and critical technological advances. The students will also prepare themselves for this double lecture by reading the historical milestone papers and contributing to the discussion. In the following lecture up to four students will present each a recent high impact research paper which emerged from the landmark achievements of the previously discussed milestone concepts.
InhaltMilestones and current topics of innate immunity, antigen presentatino, B cells, thymus and T cells, cytotoxic T cells and NK cells, and tumor immunology.
SkriptOriginal and review articles will be distributed by the lecturer.
LiteraturLiteraturunterlagen werden vor Beginn des Kurses auf folgender website zugänglich sein: Moodle Course Link
551-1303-00LCellular Biochemistry of Health and Disease Information Belegung eingeschränkt - Details anzeigen
Number of participants limited to 20.
W4 KP2SV. Korkhov, Y. Barral, J. Fernandes de Matos, B. Kornmann, R. Kroschewski, M. Peter, P. Picotti, A. E. Smith, K. Weis
KurzbeschreibungDuring this Masters level seminar style course, students will explore current research topics in cellular biochemistry focused on the structure, function and regulation of selected cell components, and the consequences of dysregulation for pathologies.
LernzielStudents will work with experts toward a critical analysis of cutting-edge research in the domain of cellular biochemistry, with emphasis on normal cellular processes and the consequences of their dysregulation. At the end of the course, students will be able to introduce, present, evaluate, critically discuss and write about recent scientific articles in the research area of cellular biochemistry.
InhaltGuided by an expert in the field, students will engage in classical round-table style discussions of current literature with occasional frontal presentations. Students will alternate as discussion leaders throughout the semester, with the student leader responsible to briefly summarize key general knowledge and context of the assigned primary research paper. Together with the faculty expert, all students will participate in discussion of the primary paper, including the foundation of the biological question, specific questions addressed, key methods, key results, remaining gaps and research implications.
LiteraturThe literature will be provided during the course
Voraussetzungen / BesonderesThe course will be taught in English.
551-1323-00LGrundlagen der Biologie II: Biochemie und Molekularbiologie Information W4 KP4VK. Locher, N. Ban, R. Glockshuber, E. Weber-Ban
KurzbeschreibungDie Vorlesung vermittelt die Grundlagen der Biochemie und Molekularbiologie mit Betonung der chemischen und biophysikalischen Aspekte.
LernzielBehandelt werden Struktur-Funktionsbeziehungen in Proteinen und Nukleinsäuren, Konzepte der Proteinfaltung und der biochemischen Katalyse, die wichtigsten an zellulärer Energiegewinnung und -Speicherung beteiligten Stoffwechselvorgänge, die Biosynthese von Aminosäuren, Zucker, Nukleotiden, Fetten und Steroiden, sowie eine detaillierte Diskussion von Replikation, Transkription und Translation.
Skriptkein Skript
Literaturobligatorisch: "Biochemistry",
Autoren: Berg/Tymoczko/Stryer, 8th edition, Palgrave Macmillan, International edition (wird bei der Polybuchhandlung als englische Version vorbestellt werden)
Voraussetzungen / BesonderesEinige Vorlesungseinheiten werden in englischer Sprache gehalten.
636-0017-00LComputational Biology Information W6 KP3G + 2AT. Stadler, C. Magnus, T. Vaughan
KurzbeschreibungThe aim of the course is to provide up-to-date knowledge on how we can study biological processes using genetic sequencing data. Computational algorithms extracting biological information from genetic sequence data are discussed, and statistical tools to understand this information in detail are introduced.
LernzielAttendees will learn which information is contained in genetic sequencing data and how to extract information from this data using computational tools. The main concepts introduced are:
* stochastic models in molecular evolution
* phylogenetic & phylodynamic inference
* maximum likelihood and Bayesian statistics
Attendees will apply these concepts to a number of applications yielding biological insight into:
* epidemiology
* pathogen evolution
* macroevolution of species
InhaltThe course consists of four parts. We first introduce modern genetic sequencing technology, and algorithms to obtain sequence alignments from the output of the sequencers. We then present methods for direct alignment analysis using approaches such as BLAST and GWAS. Second, we introduce mechanisms and concepts of molecular evolution, i.e. we discuss how genetic sequences change over time. Third, we employ evolutionary concepts to infer ancestral relationships between organisms based on their genetic sequences, i.e. we discuss methods to infer genealogies and phylogenies. Lastly, we introduce the field of phylodynamics, the aim of which is to understand and quantify population dynamic processes (such as transmission in epidemiology or speciation & extinction in macroevolution) based on a phylogeny. Throughout the class, the models and methods are illustrated on different datasets giving insight into the epidemiology and evolution of a range of infectious diseases (e.g. HIV, HCV, influenza, Ebola). Applications of the methods to the field of macroevolution provide insight into the evolution and ecology of different species clades. Students will be trained in the algorithms and their application both on paper and in silico as part of the exercises.
SkriptLecture slides will be available on moodle.
LiteraturThe course is not based on any of the textbooks below, but they are excellent choices as accompanying material:
* Yang, Z. 2006. Computational Molecular Evolution.
* Felsenstein, J. 2004. Inferring Phylogenies.
* Semple, C. & Steel, M. 2003. Phylogenetics.
* Drummond, A. & Bouckaert, R. 2015. Bayesian evolutionary analysis with BEAST.
Voraussetzungen / BesonderesBasic knowledge in linear algebra, analysis, and statistics will be helpful. Programming in R will be required for the project work (compulsory continuous performance assessments). We provide an R tutorial and help sessions during the first two weeks of class to learn the required skills. However, in case you do not have any previous experience with R, we strongly recommend to get familiar with R prior to the semester start. For the D-BSSE students, we highly recommend the voluntary course „Introduction to Programming“, which takes place at D-BSSE from Wednesday, September 12 to Friday, September 14, i.e. BEFORE the official semester starting date Link
For the Zurich-based students without R experience, we recommend the R course Link, or working through the script provided as part of this R course.
636-0108-00LBiological Engineering and Biotechnology
Attention: This course was offered in previous semesters with the number: 636-0003-00L "Biological Engineering and Biotechnology". Students that already passed course 636-0003-00L cannot receive credits for course 636-0108-00L.
W4 KP3VM. Fussenegger
KurzbeschreibungBiological Engineering and Biotechnology will cover the latest biotechnological advances as well as their industrial implementation to engineer mammalian cells for use in human therapy. This lecture will provide forefront insights into key scientific aspects and the main points in industrial decision-making to bring a therapeutic from target to market.
LernzielBiological Engineering and Biotechnology will cover the latest biotechnological advances as well as their industrial implementation to engineer mammalian cells for use in human therapy. This lecture will provide forefront insights into key scientific aspects and the main points in industrial decision-making to bring a therapeutic from target to market.
Inhalt1. Insight Into The Mammalian Cell Cycle. Cycling, The Balance Between Proliferation and Cancer - Implications For Biopharmaceutical Manufacturing. 2. The Licence To Kill. Apoptosis Regulatory Networks - Engineering of Survival Pathways To Increase Robustness of Production Cell Lines. 3. Everything Under Control I. Regulated Transgene Expression in Mammalian Cells - Facts and Future. 4. Secretion Engineering. The Traffic Jam getting out of the Cell. 5. From Target To Market. An Antibody's Journey From Cell Culture to The Clinics. 6. Biology and Malign Applications. Do Life Sciences Enable the Development of Biological Weapons? 7. Functional Food. Enjoy your Meal! 8. Industrial Genomics. Getting a Systems View on Nutrition and Health - An Industrial Perspective. 9. IP Management - Food Technology. Protecting Your Knowledge For Business. 10. Biopharmaceutical Manufacturing I. Introduction to Process Development. 11. Biopharmaceutical Manufacturing II. Up- stream Development. 12. Biopharmaceutical Manufacturing III. Downstream Development. 13. Biopharmaceutical Manufacturing IV. Pharma Development.
SkriptHandout during the course.
636-0507-00LSynthetic Biology II Belegung eingeschränkt - Details anzeigen
Students in the MSc Programme Biotechnology (Programme Regulation 2017) may select Synthetic Biology II instead of the Research Project 1.
W8 KP4AS. Panke, Y. Benenson, J. Stelling
Kurzbeschreibung7 months biological design project, during which the students are required to give presentations on advanced topics in synthetic biology (specifically genetic circuit design) and then select their own biological system to design. The system is subsequently modeled, analyzed, and experimentally implemented. Results are presented at an international student competition at the MIT (Cambridge).
LernzielThe students are supposed to acquire a deep understanding of the process of biological design including model representation of a biological system, its thorough analysis, and the subsequent experimental implementation of the system and the related problems.
InhaltPresentations on advanced synthetic biology topics (eg genetic circuit design, adaptation of systems dynamics, analytical concepts, large scale de novo DNA synthesis), project selection, modeling of selected biological system, design space exploration, sensitivity analysis, conversion into DNA sequence, (DNA synthesis external,) implementation and analysis of design, summary of results in form of scientific presentation and poster, presentation of results at the iGEM international student competition (Link).
SkriptHandouts during course
Voraussetzungen / BesonderesThe final presentation of the project is typically at the MIT (Cambridge, US). Other competing schools include regularly Imperial College, Cambridge University, Harvard University, UC Berkeley, Princeton Universtiy, CalTech, etc.

This project takes place between end of Spring Semester and beginning of Autumn Semester. Registration in April.

Please note that the number of ECTS credits and the actual work load are disconnected.
701-1703-00LEvolutionary Medicine for Infectious Diseases Belegung eingeschränkt - Details anzeigen
Number of participants limited to 35.
W3 KP2GA. Hall
KurzbeschreibungThis course explores infectious disease from both the host and pathogen perspective. Through short lectures, reading and active discussion, students will identify areas where evolutionary thinking can improve our understanding of infectious diseases and, ultimately, our ability to treat them effectively.
LernzielStudents will learn to (i) identify evolutionary explanations for the origins and characteristics of infectious diseases in a range of organisms and (ii) evaluate ways of integrating evolutionary thinking into improved strategies for treating infections of humans and animals. This will incorporate principles that apply across any host-pathogen interaction, as well as system-specific mechanistic information, with particular emphasis on bacteria and viruses.
InhaltWe will cover several topics where evolutionary thinking is relevant to understanding or treating infectious diseases. This includes: (i) determinants of pathogen host range and virulence, (ii) dynamics of host-parasite coevolution, (iii) pathogen adaptation to evade or suppress immune responses, (iv) antimicrobial resistance, (v) evolution-proof medicine. For each topic there will be a short (< 20 minutes) introductory lecture, before students independently research the primary literature and develop discussion points and questions, followed by interactive discussion in class.
LiteraturThe focus is on primary literature, but for some parts the following text books provide good background information:

Schmid Hempel 2011 Evolutionary Parasitology
Stearns & Medzhitov 2016 Evolutionary Medicine
Voraussetzungen / BesonderesA basic understanding of evolutionary biology, microbiology or parasitology will be advantageous but is not essential.
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